Characterization of a newly emerged genetic cluster of H1N1 and H1N2 swine influenza virus in the United States
Identifieur interne : 001189 ( Main/Exploration ); précédent : 001188; suivant : 001190Characterization of a newly emerged genetic cluster of H1N1 and H1N2 swine influenza virus in the United States
Auteurs : Amy L. Vincent [États-Unis] ; Wenjun Ma [États-Unis] ; Kelly M. Lager [États-Unis] ; Marie R. Gramer [États-Unis] ; Juergen A. Richt [États-Unis] ; Bruce H. Janke [États-Unis]Source :
- Virus Genes [ 0920-8569 ] ; 2009-10-01.
Descripteurs français
- Wicri :
- topic : Porcin.
English descriptors
- KwdEn :
Abstract
Abstract: H1 influenza A viruses that were distinct from the classical swine H1 lineage were identified in pigs in Canada in 2003–2004; antigenic and genetic characterization identified the hemagglutinin (HA) as human H1 lineage. The viruses identified in Canadian pigs were human lineage in entirety or double (human–swine) reassortants. Here, we report the whole genome sequence analysis of four human-like H1 viruses isolated from U.S. swine in 2005 and 2007. All four isolates were characterized as triple reassortants with an internal gene constellation similar to contemporary U.S. swine influenza virus (SIV), with HA and neuraminidase (NA) most similar to human influenza virus lineages. A 2007 human-like H1N1 was evaluated in a pathogenesis and transmission model and compared to a 2004 reassortant H1N1 SIV isolate with swine lineage HA and NA. The 2007 isolate induced disease typical of influenza virus and was transmitted to contact pigs; however, the kinetics and magnitude differed from the 2004 H1N1 SIV. This study indicates that the human-like H1 SIV can efficiently replicate and transmit in the swine host and now co-circulates with contemporary SIVs as a distinct genetic cluster of H1 SIV.
Url:
DOI: 10.1007/s11262-009-0386-6
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001501
- to stream Istex, to step Curation: 001501
- to stream Istex, to step Checkpoint: 000307
- to stream Main, to step Merge: 001199
- to stream Main, to step Curation: 001189
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Characterization of a newly emerged genetic cluster of H1N1 and H1N2 swine influenza virus in the United States</title>
<author><name sortKey="Vincent, Amy L" sort="Vincent, Amy L" uniqKey="Vincent A" first="Amy L." last="Vincent">Amy L. Vincent</name>
</author>
<author><name sortKey="Ma, Wenjun" sort="Ma, Wenjun" uniqKey="Ma W" first="Wenjun" last="Ma">Wenjun Ma</name>
</author>
<author><name sortKey="Lager, Kelly M" sort="Lager, Kelly M" uniqKey="Lager K" first="Kelly M." last="Lager">Kelly M. Lager</name>
</author>
<author><name sortKey="Gramer, Marie R" sort="Gramer, Marie R" uniqKey="Gramer M" first="Marie R." last="Gramer">Marie R. Gramer</name>
</author>
<author><name sortKey="Richt, Juergen A" sort="Richt, Juergen A" uniqKey="Richt J" first="Juergen A." last="Richt">Juergen A. Richt</name>
</author>
<author><name sortKey="Janke, Bruce H" sort="Janke, Bruce H" uniqKey="Janke B" first="Bruce H." last="Janke">Bruce H. Janke</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:9BDE0DC8D98294793B7AC0C36FF3BED84A807BAF</idno>
<date when="2009" year="2009">2009</date>
<idno type="doi">10.1007/s11262-009-0386-6</idno>
<idno type="url">https://api.istex.fr/ark:/67375/VQC-CGGFKFNH-Q/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">001501</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001501</idno>
<idno type="wicri:Area/Istex/Curation">001501</idno>
<idno type="wicri:Area/Istex/Checkpoint">000307</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000307</idno>
<idno type="wicri:doubleKey">0920-8569:2009:Vincent A:characterization:of:a</idno>
<idno type="wicri:Area/Main/Merge">001199</idno>
<idno type="wicri:Area/Main/Curation">001189</idno>
<idno type="wicri:Area/Main/Exploration">001189</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Characterization of a newly emerged genetic cluster of H1N1 and H1N2 swine influenza virus in the United States</title>
<author><name sortKey="Vincent, Amy L" sort="Vincent, Amy L" uniqKey="Vincent A" first="Amy L." last="Vincent">Amy L. Vincent</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Virus and Prion Diseases of Livestock Research Unit, National Animal Disease Center, USDA-ARS, 2300 Dayton Road, 50010, Ames, IA</wicri:regionArea>
<placeName><region type="state">Iowa</region>
</placeName>
</affiliation>
<affiliation></affiliation>
</author>
<author><name sortKey="Ma, Wenjun" sort="Ma, Wenjun" uniqKey="Ma W" first="Wenjun" last="Ma">Wenjun Ma</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Virus and Prion Diseases of Livestock Research Unit, National Animal Disease Center, USDA-ARS, 2300 Dayton Road, 50010, Ames, IA</wicri:regionArea>
<placeName><region type="state">Iowa</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA</wicri:regionArea>
<placeName><region type="state">Iowa</region>
<settlement type="city">Ames (Iowa)</settlement>
</placeName>
<orgName type="university">Université d'État de l'Iowa</orgName>
</affiliation>
</author>
<author><name sortKey="Lager, Kelly M" sort="Lager, Kelly M" uniqKey="Lager K" first="Kelly M." last="Lager">Kelly M. Lager</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Virus and Prion Diseases of Livestock Research Unit, National Animal Disease Center, USDA-ARS, 2300 Dayton Road, 50010, Ames, IA</wicri:regionArea>
<placeName><region type="state">Iowa</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gramer, Marie R" sort="Gramer, Marie R" uniqKey="Gramer M" first="Marie R." last="Gramer">Marie R. Gramer</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Minnesota Veterinary Diagnostic Laboratory, University of Minnesota, St. Paul, MN</wicri:regionArea>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Richt, Juergen A" sort="Richt, Juergen A" uniqKey="Richt J" first="Juergen A." last="Richt">Juergen A. Richt</name>
<affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Virus and Prion Diseases of Livestock Research Unit, National Animal Disease Center, USDA-ARS, 2300 Dayton Road, 50010, Ames, IA</wicri:regionArea>
<placeName><region type="state">Iowa</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Janke, Bruce H" sort="Janke, Bruce H" uniqKey="Janke B" first="Bruce H." last="Janke">Bruce H. Janke</name>
<affiliation wicri:level="4"><country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA</wicri:regionArea>
<placeName><region type="state">Iowa</region>
<settlement type="city">Ames (Iowa)</settlement>
</placeName>
<orgName type="university">Université d'État de l'Iowa</orgName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Virus Genes</title>
<title level="j" type="abbrev">Virus Genes</title>
<idno type="ISSN">0920-8569</idno>
<idno type="eISSN">1572-994X</idno>
<imprint><publisher>Springer US; http://www.springer-ny.com</publisher>
<pubPlace>Boston</pubPlace>
<date type="published" when="2009-10-01">2009-10-01</date>
<biblScope unit="volume">39</biblScope>
<biblScope unit="issue">2</biblScope>
<biblScope unit="page" from="176">176</biblScope>
<biblScope unit="page" to="185">185</biblScope>
</imprint>
<idno type="ISSN">0920-8569</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0920-8569</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>H1N1</term>
<term>H1N2</term>
<term>Influenza A virus</term>
<term>Reassortment</term>
<term>Swine</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Porcin</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Abstract: H1 influenza A viruses that were distinct from the classical swine H1 lineage were identified in pigs in Canada in 2003–2004; antigenic and genetic characterization identified the hemagglutinin (HA) as human H1 lineage. The viruses identified in Canadian pigs were human lineage in entirety or double (human–swine) reassortants. Here, we report the whole genome sequence analysis of four human-like H1 viruses isolated from U.S. swine in 2005 and 2007. All four isolates were characterized as triple reassortants with an internal gene constellation similar to contemporary U.S. swine influenza virus (SIV), with HA and neuraminidase (NA) most similar to human influenza virus lineages. A 2007 human-like H1N1 was evaluated in a pathogenesis and transmission model and compared to a 2004 reassortant H1N1 SIV isolate with swine lineage HA and NA. The 2007 isolate induced disease typical of influenza virus and was transmitted to contact pigs; however, the kinetics and magnitude differed from the 2004 H1N1 SIV. This study indicates that the human-like H1 SIV can efficiently replicate and transmit in the swine host and now co-circulates with contemporary SIVs as a distinct genetic cluster of H1 SIV.</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Iowa</li>
<li>Minnesota</li>
</region>
<settlement><li>Ames (Iowa)</li>
</settlement>
<orgName><li>Université d'État de l'Iowa</li>
</orgName>
</list>
<tree><country name="États-Unis"><region name="Iowa"><name sortKey="Vincent, Amy L" sort="Vincent, Amy L" uniqKey="Vincent A" first="Amy L." last="Vincent">Amy L. Vincent</name>
</region>
<name sortKey="Gramer, Marie R" sort="Gramer, Marie R" uniqKey="Gramer M" first="Marie R." last="Gramer">Marie R. Gramer</name>
<name sortKey="Janke, Bruce H" sort="Janke, Bruce H" uniqKey="Janke B" first="Bruce H." last="Janke">Bruce H. Janke</name>
<name sortKey="Lager, Kelly M" sort="Lager, Kelly M" uniqKey="Lager K" first="Kelly M." last="Lager">Kelly M. Lager</name>
<name sortKey="Ma, Wenjun" sort="Ma, Wenjun" uniqKey="Ma W" first="Wenjun" last="Ma">Wenjun Ma</name>
<name sortKey="Ma, Wenjun" sort="Ma, Wenjun" uniqKey="Ma W" first="Wenjun" last="Ma">Wenjun Ma</name>
<name sortKey="Richt, Juergen A" sort="Richt, Juergen A" uniqKey="Richt J" first="Juergen A." last="Richt">Juergen A. Richt</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001189 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001189 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= H2N2V1 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:9BDE0DC8D98294793B7AC0C36FF3BED84A807BAF |texte= Characterization of a newly emerged genetic cluster of H1N1 and H1N2 swine influenza virus in the United States }}
This area was generated with Dilib version V0.6.33. |